Acai berries are known to contain high levels of antioxidants. A recent study conducted at CCRM has shown improvements in clinical outcomes following acai berry supplementation among patients undergoing IVF cycles. By regulating the oxidant-antioxidant balance in the body and reducing oxidative stress, antioxidant-rich foods, like acai berries, contribute to benefiting one’s reproductive health.
CoQ10 – CoQ10 is a coenzyme that aids in energy production in the mitochondria and acts as an antioxidant. Energy production plays an important role in oocyte maturation and embryo development. Further, it has been suggested that the decrease in production and levels of CoQ10 with age may correlate with age-related decline in fertility. Clinical studies have indicated that CoQ10 supplementation can improve ovarian response to stimulatory medications and higher fertilization rates, especially among patients diagnosed with diminished ovarian reserve. (Pretreatment with coenzyme Q10 improves ovarian response and embryo quality in low-prognosis young women with decreased ovarian reserve: a randomized controlled trial (nih.gov))
Vitamin D3 is a widely recommended and studied steroid hormone due to its multiple roles in the body. Specific to fertility, several studies have suggested that healthy levels of Vitamin D in the ovarian follicular fluid can improve implantation rates after an embryo transfer (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555056/). Vitamin D supplementation has also proven to benefit women with PCOS. PCOS is a condition often associated with insulin resistance and hyperinsulinemia. By increasing insulin sensitivity, Vitamin D has shown to provide therapeutic benefits for PCOS patients (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086222/).
Inositol is a sugar and vitamin-like substance commonly recommended as a dietary supplement to manage PCOS and certain mental disorders. It has been shown to increase ovulation induction and decrease the amount of gonadotropins used among women with and without PCOS during IVF cycles. (Inositol supplement improves clinical pregnancy rate in infertile women undergoing ovulation induction for ICSI or IVF-ET - PubMed (nih.gov))
Resveratrol is a polyphenolic compound found in plants. Due to its antioxidant properties and ability to promote mitochondrial function, the compound and its reproductive benefits have been subject to numerous studies. These studies have reported that resveratrol supplementation improved oocyte maturation, fertilization, and subsequently, the formation of blastocysts in both aged mice and female patients (Resveratrol improves in vitro maturation of oocytes in aged mice and humans - PubMed (nih.gov)).
Supplements can be taken to improve egg and ovarian health. At Generation Next Fertility, we recommend our patients to incorporate the following into their diet:
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