How is PRP used for IVF and other Fertility Treatments?

PRP is used in several fertility treatments, including IUI and IVF, to assist with and improve:

It is most often used in those who have undergone multiple IVF cycles with a history of recurrent implantation failure (RIF), a condition in which multiple IVF transfers do not result in pregnancy despite high-quality embryos being transferred on multiple occasions. PRP is usually tried before turning to donor egg IVF, but may be used alongside donor egg cycles along with other supporting treatments focusing on reproductive immunology.

PRP for Egg Quantity & Quality
PRP could also be used to encourage an improvement in egg quality, ovarian rejuvenation, and response to stimulation medications.

There are two ways/procedures in which PRP may be used to improve oocyte quality and quantity

Intraovarian PRP
This procedure involves injecting 1-3 milliliters of PRP directly into the ovaries. This procedure is done under monitored anesthesia care by a physician. During the procedure, a needle with the PRP is guided via ultrasound through the vaginal wall and into the ovaries where the PRP will then be deposited.

The procedure is ideally done between 1-3 months PRIOR to the start of an IVF stimulation. It may be done at the time of an egg retrieval, but this would only be beneficial if the person were to undergo another IVF stimulation cycle.

High Volume Intrauterine PRP
During a high volume intrauterine PRP procedure, 8-10 milliliters are infused slowly into the uterus using an SHG catheter (with a balloon). During the process, the plasma will flow out of the uterus, through the fallopian tubes, and bathe the ovaries in the plasma. After the infusion process is complete, the individual will rest for 10 minutes with the catheter in place.

PRP for Uterine Lining Growth & Endometrial Receptivity (PRP Intrauterine Wash):
PRP may be used to improve the endometrial receptivity of the uterine lining prior to an embryo transfer. This is typically done 48 hours prior to the anticipated embryo transfer. During the procedure, approximately 3-5 milliliters are infused in the uterus using an IUI catheter.

If the infusions are intended for lining development (usually for someone with a history of failing to develop an adequate uterine lining) the uterine wash may be performed in a series of procedures. The first PRP infusion would be done at the initial lining check and then repeated 72 hours later if the lining remains inadequate.


*PRP Therapy is an experimental treatment