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Injectable Medications

Injectable Medications 2018-09-11T19:25:55+00:00
Stimulation Medication Fertility
Trigger Medication Fertility
Supression Medication Fertility

Fertility medications that are given by injection. They contain Follicle Stimulating Hormone (FSH) alone, or in a combination of Follicle Stimulating Hormone (FSH) with Luteinizing Hormone (LH). When these medications are given as injectables, they will work directly on the ovaries causing simultaneous growth of several follicles. Gonadatropins in general are started early in the cycle.

A) Brand Name: Follistim AQ – Generic Name: Follitropin Beta

Follistim contains only the FSH hormone, providing the extra push needed for the ovaries to stimulate follicles simultaneously.

Medication Route: Injected subcutaneously into fat of lower abdomen.

To inject the medication you first need a follistim pen device. The medication cartridge is then loaded into the pen and a needle attached to the pen for the medication to be administered.

Common side effects: Discomfort, bruising and soreness at site of injection (we always recommend alternating site of injections daily). Bloating, nausea, cramping, and breast pain can occur and can be related to Ovarian Hyperstimulation Syndrome (OHSS).

B) Brand Name: Gonal-f – Generic Name: Follitropin Alfa

Gonal-f contains only the FSH hormone its purpose is to provide an extra push for the ovaries to stimulate follicles simultaneously.

Medication Route: Injected subcutaneously into fat of lower abdomen.

Gonal-f is a prefilled pen so in order to administer the medication all you have to do is attach the needles dispensed with the pre-filled pen and inject.

Common side effects: Discomfort, bruising and soreness at site of injection (we always recommend alternating site of injections daily). Bloating, nausea, cramping, and breast pain can occur and could be related to OHSS.

You can use Follistim and Gonal-f interchangeably. The selection of which one will be used in your cycle is usually dependent on insurance coverage and/or cost effectiveness at your local pharmacy.

C) Brand Name: Menopur – Generic Name: Menoptropins

Menopur contains both FSH and LH hormone, providing the extra push needed for the ovaries to stimulate follicles simultaneously.

Medication Route: Injected subcutaneously into fat of lower abdomen.

Menopur comes in 75 unit vials.

To inject Menopur you will need a 3ml syringe, the Q cap, and a 27 gauge ½ inch needle.

Menopur requires reconstitution as it comes in a powder solution. Our nursing team will gladly provide teaching classes for how to reconstitute menopur.

Common side effects: Discomfort, bruising and soreness at site of injection (we always recommend alternating site of injections daily). Sinus inflammation and a stuffy nose may occur. Bloating , nausea, head ache, cramping, and breast pain can also occur and may be related to OHSS.

Antagonist :

The purpose of antagonist medications to block a premature LH surge in the hopes of preventing
premature ovulation.

Antagon (Ganirelix Acetate):

Ganirelix Acetate (Antagon) is a gonadotropin releasing hormone with antagonistic (GnRH antagonists) blocking activity. It is indicated for the inhibition of premature LH (luteinizing hormone) surges in women undergoing controlled ovarian hyperstimulation or IVF. Ganirelix Acetate works immediately by suppressing LH and FSH secretion. This allows for eggs to reach the level of development needed for fertilization.

It is very important to remember that once anirelix is used in a cycle it must continue to be used within a 24 hour time frame in order for it to be effective.

What are the side effects?

Abdominal pain, headache, vaginal bleeding, nausea, and injection site reaction.

Cetrotide (Cetrorelix):

Works exactly like Ganirelix. It also is a gonadotropin releasing hormone with antagonistic (GnRH antagonists) blocking activity. It is indicated for the inhibition of premature LH (luteinizing hormone) surges in women undergoing controlled ovarian hyperstimulation or IVF. It works immediately by suppressing LH and FSH secretion. This allows for eggs to reach the level of development needed for fertilization.

As with Ganirelix, it is very important to remember that once Cetrotide is used in a cycle it must continue to be used within a 24 hour time frame in order for it to be effective.

What are the side effects?

Abdominal pain, headache, vaginal bleeding, nausea, and injection site reaction.

You can use Ganirelix Acetate and Cetrotide interchangeably. The selection of which one will be used in your cycle is usually dependent on insurance coverage and/or cost effectiveness at your local pharmacy.

Trigger medications to induce ovulation:

  • Novarel (Intramuscular/Subcutaneous)
  • Pregnyl (Intramuscular/Subcutaneous)
  • Ovidrel (Subcutaneous)
  • Human Chorionic Gonadotropin (HCG) Intramuscular/Subcutaneous

Trigger medications to induce ovulation:

How does it work?

HCG mimics the action of the LH surge and stimulates the release of an egg by causing ovulation within the next 36-38 hours. This allows us to schedule the timing of the egg retrieval as close to ovulation as possible, therefore increasing the chances of a mature egg.

Pregnyl, HCG, and Novarel come in 10,000 unit powder vials. They require reconstitution.

Ovidrel: Comes in a prefilled syringe.

What are the side effects?

Headache; feeling restless or irritable; mild swelling, mild cramping or water weight gain; depression; breast tenderness or swelling; or pain, swelling, or irritation where the injection is given.

You can typically use Novarel, Pregnyl, HCG, and Ovidrel interchangeably. The selection of which one will be used in your cycle is usually dependent on insurance coverage and/or cost effectiveness at your local pharmacy.

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